20
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T60025 | Eciruciclib | CDK | |
Eciruciclib is an inhibitor of CDK with antitumor properties. | |||
T5673 | Senexin A | CDK | |
Senexin A is an effective and selective CDK8 inhibitor that also inhibits CDK19 with Kd values of 0.83 microns and 0.31 microns, respectively. | |||
T7789 | DRB | HIV Protease | |
DRB is a nucleoside analog that inhibits several carboxyl-terminal domain (CTD) kinases including casein kinase II (IC50 range of 4-10 μM) | |||
T5358 | Longdaysin | ERK , Casein Kinase , CDK | |
Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 µM). It also can inhibit ERK2 (IC50: 52 µM). | |||
T7426 | ALSTERPAULLONE | Apoptosis , GSK-3 , CDK | |
Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing Effec | |||
T6312 | R547 | Ro 4584820 | Apoptosis , GSK-3 , PKA , CDK |
R547 (Ro 4584820) is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM. It is less potent to CDK7 and GSK3α/β, while inactive to other kinases. Phase 1. | |||
T5395 | BSJ-03-123 | CDK | |
BSJ-03-123 is a potent, CDK6-selective small-molecule degrader. | |||
T2356 | Ro-3306 | Apoptosis , ERK , SGK , PKA , CDK , PKC | |
RO-3306 is a selectivity ATP-competitive CDK1 inhibitor (Ki: 20 nM). The selectivity of RO-3306 for CDK1 is >15-fold higher than a diverse panel of human kinases. | |||
T16359 | NU6140 | CDK , Aurora Kinase | |
NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM). It shows 10- to 36-fold selectivity over other CDKs. NU6140 also effectively inhibits Aurora A and Aurora B (IC50s: 67 and 35 nM, respectively). It also e... | |||
T2029 | Bohemine | ERK , CDK | |
Bohemine is a cyclin-dependent kinase inhibitor. | |||
T5S1467 | Cucurbitacin E | CDK , Autophagy | |
Cucurbitacin E is a natural product isolated from the climbing stem of Cucumic melo L. It significantly suppresses the activity of the cyclin B1/CDC2 complex.Cucurbitacin E has prevention of neurodegeneration, it has pot... | |||
T39957 | CDK4/6-IN-6 | CDK | |
CDK4/6-IN-6 is a potent CDK4/CDK6 inhibitor with Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively. | |||
T4482 | CC-671 | Others , CDK | |
CC-671 is a dual TTK protein kinase (IC50: 0.005 μM) /CLK2 (IC50: 0.006 μM) inhibitor. | |||
T10436 | AZD4573 | CDK | |
AZD4573 is an effective and selective CDK9 inhibitor (IC50: <4 nM). It enables transient target engagement for the treatment of hematologic malignancies. | |||
T14901 | CCT-251921 | CDK | |
CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor (IC50: 2.3 nM). | |||
T8801 | SRI-29329 | CDK | |
SRI-29329 is a potent, specific inhibitor of CDC-like kinase (with IC50 of 78 nM, 16 nM and 86 nM for CLK1, CLK2 and CLK4, respectively). | |||
T8484 | JSH-150 | CDK | |
JSH-150 is a highly selective CDK9 inhibitor(IC50 : 1 nM). | |||
T14916 | CDK2-IN-4 | CDK | |
CDK2-IN-4 is a potent and selective inhibitor of CDK2 with an IC50 of 44 nM for CDK2/cyclin A. It shows 2,000-fold selectivity over CDK1/cyclin B with IC50 of 86 uM. | |||
T8378 | AS2863619 | CDK , STAT | |
AS2863619 is an orally active inhibitor of cyclin-dependent kinase 8 (CDK8) and CDK19 (IC50s of 0.61 nM and 4.28 nM, respectively). | |||
T3352 | XL413 | cholecystokinin , Casein Kinase , Pim , CDK | |
XL-413 is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. XL-413 binds to and inhibits the activity of CDC7, which may result in the inhibition of DNA ... |